Frykten for et samfunn uten Downs syndrom

Rachel Carson Syndrom

For years some ecologists have been convinced that pesticides are contributing to a decline in amphibian species around the globe. From an apparent epidemic of deformed frogs in Minnesota to the near disappearance of yellow-legged frogs from California’s Sierra Nevada Mountains, pesticides have been considered prime suspects. This suspicion is no doubt rooted in the belief by the ecological com...

Das Hepatopulmonale Syndrom

MEN-2-Syndrom: Was gibt es Neues?

Multiple Endocrine Neoplasia Type 2 (MEN-2): An Update. Multiple endocrine neoplasia type 2 (MEN-2) is an autosomal dominant hereditary cancer syndrome. The disorder is caused by missense mutations of the RET proto-oncogene that result in their gain of function. Three distinct clinical subtypes of MEN-2 are characterized: MEN-2A, MEN-2B, and familial MTC (FMTC). The precise RET mutations may su...

Vindicating Anthony Downs

P ositive turnout rates in the United States and elsewhere are widely considered “an embarrassing limitation of the economic approach to politics” because, for any one voter, “the costs of casting a ballot in any large election are almost always greater than the potential benefits, which are dependent on the unlikely occurrence of casting the winning or tie vote in an election” ~Knack 1992, 133...

Mdm2: the ups and downs.

Mdm2 was first described 12 years ago. Interest in this oncogene has risen since its identification as a protein that binds and efficiently inactivates the p53 tumor suppressor protein. This interest was further boosted by the discovery that the mdm2 gene is actually a target for direct transcriptional activation by p53, thus defining an autoregulatory feedback loop for the intracellular modula...